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Dutasteride : New drug used to treatment male baldness

Dutasteride (Avodart), , is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). It is used to treat benign prostatic hyperplasia. It increases the risk of erectile dysfunctionand decreased sexual desire.
Mechanism of action
Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT).
Medical uses
Avodart (dutasteride) 500 µg soft capsules.Dutasteride is useful for treating benign prostatic hyperplasia (BPH); colloquially known as an “enlarged prostate”.
In those who are being regularly screened, 5-alpha-reductase inhibitors such as finasteride and dutasteride reduce the overall risk of being diagnosed with prostate cancer; however, there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases
Dutasteride versus finasteride
Finasteride is also approved for the treatment of benign prostatic hyperplasia, or BPH. The medications belong to the same class of drugs.
Dutasteride inhibits two of the three isoforms of 5-alpha reductase, I and II, whereas finasteride only inhibits type II, and has a much shorter half-life. Bexlosteride is an isoform I selective inhibitor,albeit with limited commercial availability

Adverse effects
1. Sexual effects This class of medications increases rates of erectile dysfunction (with between 5% and 9% developing problems after starting their use).This is linked to lower quality of life and can cause stress in relationships.There is also an association with lowered sexual desire.It has been reported that these adverse sexual side effects may persist even after discontinuation of the drug.
2. Prostate cancer The FDA has added a warning to dutasteride about an increased risk of high-grade prostate cancer.While the potential for positive, negative or neutral changes to the potential risk of developing prostate cancer with dutasteride has not been established, evidence has suggested it may temporarily reduce the growth and prevalence of benign prostate tumors, but could also mask the early detection of prostate cancer. The primary area for concern is for patients who may develop prostate cancer whilst taking dutasteride for benign prostatic hyperplasia, which in turn could delay diagnosis and early treatment of the prostate cancer, thereby potentially increasing the risk of these patients developing high-grade prostate cancer.
Contraindications

Children and women who are or may become pregnant, and people with known significant hypersensitivity (e.g., serious skin reactions, angioedema) to dutasteride or finasteride should not take dutasteride. Exposure to dutasteride and other 5-alpha reductase inhibitors during pregnancy can cause birth defects. Since these medications are readily absorbed through the skin, women who are or may become pregnant should not handle them and if they come into contact with leaking capsules, the contact area should be washed immediately in soapy water. People taking dutasteride should not donate blood and, due to its long half-life, should also not donate blood for at least 6 months after the cessation of treatment.

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Exilis: Monopolar RF Machine 2 in 1 for Skin Tightening and Body Contouring

The Exilis® Elite is a non-invasive face and body contouring device designed to tighten skin while reducing fat and signs of fine lines and wrinkles.
It uses a combination of monopolar radio frequency (RF) energy, ultrasound to stimulate fat lipolysis (the breakdown of fat cells) and collagen remodelling (for skin tightening), alongside skin cooking, helping to contour the body and face.
How does it work?
The Exilis Elite uses a combination of radiofrequency energy (3.4Mhz up to 120 Watts), ultrasound and skin cooling to deliver controlled heating to target deep tissue, addressing deeper wrinkles, sagging skin and jowls, as well as the superficial skin layer, treating finer lines.
License status
The Exilis Elite was granted European CE Mark certification in 2011.It has also been approved by the U.S. FDA (Food & Drug Administration) and cleared for the non-invasive treatment of dermatologic wrinkles and rhytids
What is it used to treat?
The Exilis Elite is used to treat everything from superficial, fine lines to deep wrinkles within the deep tissue on the face, neck and body. Skin becomes smoother and lines are reduced, while the body and face are reshaped and recontoured.
– Fat deposits in hard-to-reach areas can be reduced, all with long-lasting results provided that you continue to maintain a healthy diet and lifestyle.
It is suitable for those with stubborn, mild to moderate fat deposits, and can postpone or even eliminate the need for more invasive treatments, like liposuction, in the future.It is not a weight loss solution.
Exilis Elite is used to treat love handles, bingo wings (flabby arms), saddle bags on hips and thighs, post-baby tummies, turkey necks and jowling in the face

 

                                                                                                                                         

About Exilis Elite Body Contouring & Tightening Technology
The new Exilis Elite offers improvement with the delivery of cooling and heating that dramatically improve results. Key benefits of the Exilis Elite is that the RF energy is able to penetrate up to 4cm deep into the fat and deliver to the fat a temperature greater than 44.2 Celsius. Why is that important? Clinical research has proven that not only can you cause a fat cell to lose its lipids through heating, but if you maintain a temperature of 44.2C for 4-5 minutes, fat cell destruction can occur as well.
How long does it last?
According to clinical data, Exilis Elite results are generally permanent, provided that you maintain your weight following the treatment. Its use to treat cellulite is not-permanent, however, as this can easily reoccur over time.
A European study demonstrated significant circumferential reduction in all 58 trial volunteers after 4-5 treatments. Another study demonstrated longevity of results up to at least 18 months.
The longevity of the results will depend on your genetic predisposition to ageing and your lifestyle; you may need top-up treatments to maintain the results
Side effects & risks

Side effects are generally minimal. You may notice some pinkness or redness to the skin immediately following the treatment but this typically subsides within 15-30 minutes. Skin may be slightly tender to the touch for a little time afterwards, but this is not always the case. Very rare risks reported include numbness, swelling (oedema), blistering, scarring, allergic reactions and nausea.

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Ulthera (Ultherapy®) : non-surgical face lift indication

About Ulthera
Ulthera, Inc. is a global medical device company focused on developing and commercializing technologies for aesthetic and medical applications using its therapeutic ultrasound platform technology.
The Ulthera® System is the first and only energy-based device to receive U.S. FDA clearance for a non-invasive aesthetic lift indication. It is used in a procedure known as Ultherapy®, which is an FDA-cleared treatment to lift skin above the eyebrow, on the neck , under the chin ,on the upper chest,etc
How is Ultherapy different from other cosmetic procedures
Ultherapy targets deep tissue below the skin, an area typically reached with cosmetic surgery. Ultherapy also provides ultrasound imaging, which allows  doctors to actually see the layers of tissue that are targeted during the treatment, and thus ensure the energy is delivered where it will be most effective.
Who is a good candidate for Ultherapy?
Someone with skin that has “relaxed” to the point of looking less firm. A lowered eyebrow line or sagging skin on the neck or the jowls, is often the first sign of “maturing” skin. Typically, those in their thirties and older who have mild to moderate skin laxity are candidates. Ultherapy is also a good option for people who want to “stay ahead of the game” as well as those looking to prolong the effects of cosmetic surgery.
What results can be expected?
Ultherapy addresses mild to moderate loose or sagging skin by reconditioning and renewing the collagen underlying the skin. Ultherapy can lift the brow, which in turn reduces excess skin on the lids, opens up the eyes, and gives a more refreshed look overall. It can also improve the appearance of loose skin in the jowls or neck.

How does Ultherapy work?
Before we can delve into why Ultherapy works so well, we’ll need a quick anatomy lesson. The skin is composed of layers, not unlike an onion. Peel away the top epidermal layer, and you’ll find the dermal layer – beneath it is a layer of subcutaneous fat. Between the bones and the fat is the SMAS – the Superficial Muscular Aponeurotic System – gliding membrane consisting of connective tissue (a tissue rich in collagen) and muscle. The SMAS, through many extensions, attaches to the layers piled on top of it: the subcutaneous and the epidermal-dermal layer.
It’s no wonder the SMAS is nicknamed the “face’s foundation.” Ulthera uses this structure, heating it with sound waves and thus tightening and lifting the face through all its layers to create a youthful, more natural-looking appearance. Among the youth-inducing results are lifted jowls, tightened muscles, and the improvement of sagging skin. Ultherapy delivers focused ultrasound energy below the surface of the skin to stimulate the body’s creation of new collagen. As a result, skin will lift and tone over a period of several weeks.
The Technology Behind Ulthera
What distinguishes Ulthera from lasers is the precision built into Ulthera – the DeepSEE technology. This technology not only heats the underlying skin, but also allows doctors to see which areas they’re targeting and treat these areas with precision. In a sense, DeepSEE allows doctors to rehearse before actually treating areas.
An initial ultrasound is used to find problem areas, which the doctor then narrows down to specific regions. The doctor then directs the sound waves to the deepest layers of the skin. One great advantage of DeepSEE technology is that not only are problem spots treated, but also the depth of the sound waves is also controlled, usually to 3 to 4 millimeters to target the SMAS.Before we can understand how the sound waves pass through the skin, we’ll need a brief physics lesson. Sound waves can only travel through a medium, such a solid, liquid, or gas. In order to maximize the sound waves absorbed into the skin and minimize reflection, a gel is used before the waves are fired into the skin. Sound waves then travel through the gel-slathered skin, vibrating until they reach areas of high-collagen concentrations (such as the SMAS) where they are absorbed and warm up the soft tissue, provoking an inflammatory response that sets off a healing response that in turn starts up collagen production

What does collagen do?
Collagen is a natural protein that gives skin its youthfulness and bounce by keeping it firmed and toned. As we age, collagen loses its strength, elasticity and the ability to stand up to the effects of gravity that pull the skin downward. Ultherapy jump starts a repair process that strengthens your existing collagen and produces fresh, new collagen.
Is Ultherapy uncomfortable or painful?
It really varies from patient to patient. Some patients tolerate the procedure well while other patients experience significant discomfort or pain while the energy is being delivered. This pain and discomfort are temporary and a signal that the collagen-building process has been initiated. We have extensive experience with pain management for Ultherapy and are able to offer the highest possible level of patient comfort during the procedure. The doctors will adjust the procedure based on each patient’s response and comfort threshold and will provide numbing injections as well as oral medications as needed for patient comfort. There is no pain after the procedure and patients usually tell us that any discomfort was well worth it given the benefits to come.
How long does it take to recover?
Typically there is no downtime, and patients can return to their normal activities after treatment.
How long does it take to see results?
Patients may see some initial effect but most lifting and toning will take place over 2-3 months, as tired collagen is replaced with new, more elastic collagen. As this collagen-building process continues, further improvements can appear up to 6 months following a procedure

How long do the results last?
Patients treated with Ultherapy still have fresh young collagen a year after the procedure, but skin continues to age. Future touch-up treatments can help keep pace with the aging process, and the appropriate frequency varies for each patient.
Can Ultherapy replace a facelift?
Ultherapy is an “uplift” not a “face lift.” While it is not a replacement for surgery, it is a viable option for those not ready for a face lift or those looking to prolong the effects of cosmetic surgery.
What about treating regions other than the face?
Recent clinical research shows that Ultherapy can be effective in tightening sagging skin on the body, particularly on the chest, abdomen, under the arms and around the knees. If you are interested in areas other than the face, please schedule a consultation with  doctors to see if Ultherapy would be a good approach to tighten and smooth your trouble spots.
How does Ultherapy compare to lasers?
Lasers typically address issues in the superficial layers of the skin (e.g. fine lines, wrinkles, pigment changes). Ultherapy addresses the deep skin layer to lift and lend support to the skin. The two technologies address different areas and thus can be used together when a combined approach is desired.
Are there any side effects?
There may be slight redness for a few hours following the treatment, and it is not uncommon to experience slight swelling, tingling or tenderness to touch for a few weeks. These side effects are typically mild and temporary. It is also possible to experience certain post-procedural effects such as bruising and small areas of numbness, but these are less common and will typically dissipate over the two weeks following treatment.
How much does it cost?
Ultherapy typically costs between $ 800 and $3,000 depending on the extent of treatment. You will receive a precise estimate after your consultation with the doctors.
 Is Ultherapy safe?
Ultherapy has been cleared by the FDA after demonstrating safety in clinical studies, and tens of thousands of treatments have been performed worldwide without any significant adverse events.
How many treatments are needed?
The majority of patients only need one treatment, while those with a fair amount of laxity may need more than one treatment. Annual touch-up treatments can help slow down the rate of skin aging.
Who is a good candidate for Ultherapy?
There is a broad range of people who can benefit from Ultherapy, but typically those in their thirties and older are candidates. While this is not a replacement for surgery, there are many people who want some lifting, in order to look more refreshed and toned but are not ready for surgery (mentally, financially, or logistically). And then there are younger people who want to “stay ahead of the game” as well as those looking to prolong the effect of surgery.

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8 Points Face Lift by Fillers in advance technique


The 8 Point Lift is a specialized non-surgical facelift using dermal fillers to enhance and lift the face for a total rejuvenating effect. It is also known as the Fluid Facelift and the Liquid Lift.
The 8 Point Lift targets key areas of the mid-face to lift, contour and revitalise the whole mid-face and  lower face.
As we age we lose elasticity in our skin and gravity takes its toll on the face, drawing the skin downwards and ageing us considerably. Skin sags and thins as we get older, affecting us all in different ways and typically more so for women, whose skin is naturally thinner.
The Treatment
The 8 Point Lift uses high quality dermal fillers to restore volume to the mid face using an advanced and precise technique for total rejuvenation. It combats the soft tissue loss associated with the ageing process and offers a more complete solution compared to individual dermal filler treatments

  

   Benefits of a Fillers Face Lift vs Surgical Face Lift:

    8 Point Lift       Surgical Facelift   
Anaesthesia None General Anaesthetic
Risk of bleeding None Yes
Stitches None Yes
Scarring None Hidden scars
Downtime None At least 1 week
Natural results Yes To some extent
Affordable Yes Not for everyone

    

If there is more severe laxity then a good result is still achievable but more filler material and a different technique may be required for best results.
Is It Expensive?
The 8-point facelift is the most cost-effective method we have found for delivering results with a minimal use of injectable product. The skill is in knowing where and how to place the injections in order to influence the facial structure.
How Fast Does It Work?
As the 8-point facelift uses facial filler injections, the effects are immediate. Patients are always surprised just how much difference a few tiny injections can make.

What About After-Effects?

Using top brand modern fillers means that most of the time there are minimal or no after-effects. A little short term swelling or bruising is possible and the pin pricks where the injections are placed may show, but there are very short term effects which are easily disguised with makeup.

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Mini-Thermage (Athron C ): Skin Tightening and Body Contouring

What Is Mini-Thermage?
The Mini- Thermage® system relies on heat to tighten the underlying layers of the skin. This produces an instantaneous and marked reduction in the appearance of wrinkles, jowls, and sagging skin in the neck or brow area. Thermage® is also an effective method of skin tightening for other areas of the body. It is painless, non-invasive, and requires no recovery time, yet offers immediate and consistently excellent results
Candidates
Patients who desire more subtle results and quicker recovery times than are possible with surgical face lift procedures are often ideal candidates for Mini-Thermage. Skin tightening with the Mini-Thermage  system is also beneficial for patients who are developing prominent folds and sagging in areas of the face but are not considered suitable candidates for a traditional face lift. Mini-Thermage® is an excellent treatment option for patients who wish to reduce the appearance of subtle facial wrinkling and sagging skin. If you want to rejuvenate your face without undergoing a more invasive procedure like face lift, Mini-Thermage may be the ideal treatment for you.
Ideal Mini-Thermage Candidates
Mini-Thermage  treatments are designed for patients who desire more subtle results than are possible with a surgical face lift. Ideal candidates for the treatment include:

  • Patients who are not candidates for surgical face lift
  • Middle-aged women beginning to show signs of neck/brow/eyelid sagging
  • Middle-aged women beginning to show signs of drooping jowls/cheek folds
  • Patients who want to achieve subtle lift or tightening of the face without invasive surgery
  • Patients who have had a prior face lift and desire further tightening of the skin
  • Poor candidates for Thermage® include patients who are looking for more dramatic results, such as those that can be achieved with a surgical face lift.

Before undergoing the procedure, you will have a consultation with a cosmetic dermatologist, who will go over all of your treatment options, the cost of Mini-Thermage , and determine your candidacy.

Mini-Thermage vs. Surgical Face Lift
Mini-Thermage is a facial cosmetic treatment aimed at reducing subtle fine lines and wrinkles, cheek folds, and droopiness in the face by way of a quick, non-invasive procedure. Surgical face lift is a better option for patients who would like to achieve more dramatic and longer-lasting results. Results of face lift can last from five to ten years, whereas Mini-Thermage treatments typically last approximately two years. Face lift involves the surgical tightening of facial muscles, the rearranging of underlying facial structures, and the trimming of excess skin. Surgical face lift is also more feasible an option for patients who can afford the expense and the recovery time associated with an invasive cosmetic procedure. Mini-Thermage treatment does not require incisions or any downtime. Mini-Thermage  is also a potentially ideal alternative for patients who are not eligible for face lift.
Considerations
Although Mini-Thermage  is often suggested as an alternative to more invasive cosmetic facial procedures, patients should not consider it a substitute for face lift. Individuals who have very loose skin, heavy faces, deep jowls and wrinkles, and other more advanced signs of aging in the face may not experience significant improvement afterMini-Thermage. Additionally, individuals interested in treatment should be fully informed of Thermage® risks and treatment benefits. A skin care specialist can help evaluate your individual needs and determine if Thermage® is an appropriate option for you.
What to Expect after Treatment
Immediately following the Mini-Thermage procedure, results will be subtle, but they should be visible. The skin should be tighter and firmer, with better elasticity and a more youthful overall appearance.
Side effects from Mini-Thermage are rare and generally minor, but in some cases patients may experience mild redness, bumps, and blisters in the recently treated areas. These symptoms usually disappear on their own in a few days, though they may last for a week or more. In extremely rare cases (less than 0.08 percent of those treated), a longer-lasting complication described as a “surface irregularity” has also been reported.
Results
Mini-Thermage results vary according to the condition of the patient’s skin and especially the collagen fiber network. Mini-Thermage generally improves the appearance of each patient’s skin to some extent, but patients with healthier skin tend to experience more dramatic results.
Some Mini-Thermage results should be visible almost immediately after treatment, but one thing that makesMini-Thermage truly unique is the fact that the patient’s appearance will actually improve over the months following treatment. This is because Mini-Thermage stimulates the skin to grow new collagen of its own in addition to stimulating the existing fibers. Mini-Thermage uses the body’s natural processes to improve a patient’s appearance rather than relying on surgical techniques or artificial materials.
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X Wave therapy for cellulite reduction

What is X -Wave ?

X Wave is the new US FDA approved non-invasive aesthetic device for reduction of cellulite using acoustic wave technology. Eight to ten sessions at weekly intervals give optimal results in most patients.
The acoustic waves used in X Wave break down the adhesive fibrous bands in the skin, which lead to the puckering and dimpling of cellulite. Thus X Wave treatments gradually improve visible cellulite.
Key highlights of the XWave technology include:
• Clinically tested with good results, leading to US FDA approval of the device
• Comfortable, painless, non-invasive treatment without any side effects or downtime
• Long lasting, visible results, and high satisfaction rates reported by patients worldwide
• XWave may be safely combined with Mesotherapy, to further improve cellulite.
Tradition
The X-Wave treatment uses the laws of the Acoustic Waves Technology which has been scientifically verified for more than 30 years in several medical treatments.
Effects
• Oscillating acoustic waves induce vibration in connective tissue.
• The tissue relaxes and tightens. The firmness and elasticity of the dermis increases.
• Blood circulation and collagen production is significantly stimulated.
• Patients typically experience improvement in the skin’s texture and elasticity.

Excellent Results in:
• Anti-cellulite therapy
• Connective tissue tightening
• Skin rejuvenation and elasticity increase
• Appearance of stretch marks
• Minimazing unsightly scars
X-Wave Treatment Areas:
• Upper arms
• Love handles
• Abdomen
• Buttocks
• Thighs
Maximum Comfort for the Patient
• Painless application
• No special regimen required
• No side effects, no risks
• Long lasting visible results
• Excellent satisfaction rate reported by patients worldwide